Arsenal will take on BATE Borisov and Chelsea play Swedish side Malmo in the Europa League last 32.
Arsenal and their London rivals will both fancy their chances of progressing having gone through as group winners.
But Scottish champions Celtic have one of the toughest draws of the first knockout stage against Valencia, who dropped down from the Champions League.
Unai Emery has a phenomenal record in the Europa League having steered Sevilla to the trophy three times.
And his Arsenal side negotiated the group stage with ease, keeping five consecutive clean sheets and winning all but one of the games against Sporting Lisbon, Vorskla and Qarabag. They will now take on BATE Borisov and expect a typically hostile atmosphere in the away leg against the Belarusians.
Chelsea fans will have a trip to the Swedish coastal town of Malmo to look forward to in the new year after a near perfect group campaign.
The Blues’ perfect record in the competition this season came to an end against Vidi last week in a 2-2 draw.
EUROPA LEAGUE LAST 32 DRAW
Viktoria Plzen vs Dinamo Zagreb
Brugge vs Salzburg
Rapid Vienna vs Inter Milan
Slavia Prague vs Genk
Krasnodar vs Bayer Leverkusen
Zurich vs Napoli
Malmo vs Chelsea
Shakhtar Donetsk vs Eintracht Frankfurt
Celtic vs Valencia
Rennes vs Real Betis
Olympiacos vs Dinamo Kiev
Lazio vs Sevilla
Fenerbahce vs Zenit St Petersburg
Sporting Lisbon vs Villarreal
BATE Borisov vs Arsenal
Galatasaray vs Benfica
Brendan Rodgers will hope the Celtic Park factor can play a part when the Scottish champions host their opponents.
The Spanish side are struggling in La Liga, down in 14th place.
There were plenty of other appetising contests drawn to take place next February. Lazio, fifth in Serie A, meet five-time champions Sevilla in one of the stand-out games.
Galatasaray’s encounter with Benfica also looks to be a fascinating pairing as both sides will have expected to feature in the latter stages of the competition.