Calvert-Lewin scored on his debut to get the ball rolling, before Coady and Ings scored first international goals of their own in the second half as an inexperienced England side defeated Wales 3-0 in Thursday’s friendly encounter at Wembley.
After a bright start, the visitors faded and failed to truly test opposition keeper Pope all game.
With captain Harry Kane rested and Tammy Abraham one of three players alongside Jadon Sancho and Ben Chilwell absent for breaching coronavirus protocol rules.
Calvert-Lewin was selected by Gareth Southgate to lead the line.
The in-form Everton striker headed home from Jack Grealish’s sublime cross before Conor Coady doubled the lead eight minutes after the break.
Danny Ings then celebrated his first international goal, marking the first time three England players all scored a maiden goal in the same game since 1963, as the Three Lions completed a clinical if not textbook performance ahead of tougher assignments.
An England XI boasting just 54 appearances – the lowest since 1980 – started nervily and Kieffer Moore dragged a volley wide after a poor headed clearance from debutant Bukayo Saka.
But Calvert-Lewin marked a fine England bow by nodding home from six yards in the 26th minute when Grealish, making his first Three Lions start, hung up a peach of a cross after tying Ethan Ampadu in knots.
The lead was doubled when Kieran Trippier – who became England’s 123rd skipper in the absence of Kane – produced a fine free-kick that Coady expertly half-volleyed past Wayne Hennessey from close range.
Wales had no way back just after the hour when Tyrone Mings headed a corner back across the face of goal for Southampton striker Ings to steer acrobatically home with a lovely overhead effort.
Hennessey made a couple of smart stops to deny Ainsley Maitland-Niles and Ings late on to ensure no further damage for Wales.