Dinamo complete a remarkable comeback to dump Spurs out of the Europa League as they surrendered a two-goal lead and lost 3-0 to Dinamo Zagreb.
While it is the Croatian side who go through, they owe it all to Orsic, who scored a hat-trick on the night.
First scoring a wonderful strike into the top right corner, Orsic added another second-half goal to take this game to extra-time.
The hat-trick hero then completed his magnificent performance with a low finish past Lloris to send his team through to the quarter-finals, dumping out Mourinho’s visitors in the process.
They started slowly, subdued and were unable to lift the tempo out of their pedestrian rhythm when it mattered.
At the same time, they were fragile at the back, offering little resistance once their hosts bristled with momentum.
Dinamo Zagreb, in the throes of crisis, celebrated a famous win and Mourinho is left to pick up the pieces.
Beaten by Arsenal on Sunday, his team are seventh in the Premier League, unlikely to finish in the top four and this is another route into the Champions League closed.
It did not help to be without Heung-min Son, who was injured, and Pierre-Emile Hojbjerg, who was serving a ban but preparations must have been a breeze for Mourinho and his staff compared to those in the Dinamo dug-out
With no hopes of European glory left, Mourinho’s focus will turn to the Premier League, where Spurs sit in seventh and next face Aston Villa.
They still have hope of silverware with a cup final left against Manchester City but the Portuguese manager will be frustrated to go out like this.
Dinamo, who pulled off an unexpected comeback here, will find out their quarter-final opponents on Saturday.